Niedernhofer, L: search on Z-Library

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1

Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span

Robbins, Paul D., Jurk, Diana, Khosla, Sundeep, Kirkland, James L., LeBrasseur, Nathan K., Miller, Jordan D., Passos, JoÃ£o F., Pignolo, Robert J., Tchkonia, Tamar, Niedernhofer, Laura J.

Journal:

Annual Review of Pharmacology

Year:

2021

File:

PDF, 2.05 MB

2021

2

The Clinical Potential of Senolytic Drugs

Kirkland, James L., Tchkonia, Tamara, Zhu, Yi, Niedernhofer, Laura J., Robbins, Paul D.

Journal:

Journal of the American Geriatrics Society

Year:

2017

Language:

english

File:

PDF, 64 KB

english, 2017

3

Hsp90 inhibitors as senolytic drugs to extend healthy aging

Fuhrmann-Stroissnigg, Heike, Niedernhofer, Laura J., Robbins, Paul D.

Journal:

Year:

2018

Language:

english

File:

PDF, 1.36 MB

english, 2018

4

Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues

Yousefzadeh, Matthew J., Wilkinson, John E., Hughes, Brian, Gadela, Namrata, Ladiges, Warren C., Vo, Nam, Niedernhofer, Laura J., Huffman, Derek M., Robbins, Paul D.

Journal:

Year:

2020

File:

PDF, 1.11 MB

2020

5

Senotherapeutics for healthy ageing

Niedernhofer, Laura J., Robbins, Paul D.

Journal:

Nature Reviews Drug Discovery

Year:

2018

Language:

english

File:

PDF, 121 KB

english, 2018

6

Heterochronic Parabiosis Approach: is it Possible to Interrupt the Aging Process of the Intervertebral Disc Degeneration? An in vivo Experimental Study

Colangelo, Debora, Robbins, Paul, Nasto, Luigi Aurelio, Niedernhofer, Laura, Pola, Enrico

Journal:

Global Spine Journal

Year:

2016

File:

PDF, 81 KB

2016

7

Nuclear Genomic Instability and Aging

Niedernhofer, Laura J., Gurkar, Aditi U., Wang, Yinsheng, Vijg, Jan, Hoeijmakers, Jan H.J., Robbins, Paul D.

Journal:

Annual Review of Biochemistry

Year:

2018

Language:

english

File:

PDF, 391 KB

english, 2018

8

Hyper telomere recombination accelerates replicative senescence and may promote premature aging

R. Tanner Hagelstrom, Krastan B. Blagoev, Laura J. Niedernhofer, Edwin H. Goodwin, Susan M. Bailey and José N. Onuchic

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.44 MB

english, 2010

9

Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2 nd Scripps Symposium on the Biology of Aging

Robbins, Paul D., Niedernhofer, Laura J.

Journal:

Year:

2017

Language:

english

File:

PDF, 82 KB

english, 2017

10

Development of clinical trials to extend healthy lifespan

Justice, Jamie N., Niedernhofer, Laura, Robbins, Paul D., Aroda, Vanita R., Espeland, Mark A., Kritchevsky, Stephen B., Kuchel, George A., Barzilai, Nir

Journal:

Cardiovascular Endocrinology & Metabolism

Year:

2018

File:

PDF, 119 KB

2018

11

ISSLS Prize Winner

Nasto, Luigi A., Seo, Hyoung-Yeon, Robinson, Andria R., Tilstra, Jeremy S., Clauson, Cheryl L., Sowa, Gwendolyn A., Ngo, Kevin, Dong, Qing, Pola, Enrico, Lee, Joon Y., Niedernhofer, Laura J., Kang, Ja

Journal:

Year:

2012

Language:

english

File:

PDF, 2.70 MB

english, 2012

12

Bupivacaine decreases cell viability and matrix protein synthesis in an intervertebral disc organ model system

Dong Wang, Nam V. Vo, Gwendolyn A. Sowa, Robert A. Hartman, Kevin Ngo, So Ra Choe, William T. Witt, Qing Dong, Joon Y. Lee, Laura J. Niedernhofer, James D. Kang

Journal:

The Spine Journal

Year:

2011

Language:

english

File:

PDF, 1.04 MB

english, 2011

13

Investigating the role of DNA damage in tobacco smoking-induced spine degeneration

Nasto, Luigi A., Ngo, Kevin, Leme, Adriana S., Robinson, Andria R., Dong, Qing, Roughley, Peter, Usas, Arvydas, Sowa, Gwendolyn A., Pola, Enrico, Kang, James, Niedernhofer, Laura J., Shapiro, Steven,

Journal:

The Spine Journal

Year:

2014

Language:

english

File:

PDF, 996 KB

english, 2014

14

The Role of Cancer Therapy Agents in Intervertebral Disc Degeneration

Luigi A. Nasto, Dong Wang, Cheryl Clauson, Qing Dong, Gwendolyn A. Sowa, Peter Roughley, Paul D. Robbins, Laura Niedernhofer, James D. Kang, Nam Vo

Journal:

The Spine Journal

Year:

2012

Language:

english

File:

PDF, 48 KB

english, 2012

15

New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

Zhu, Yi, Doornebal, Ewald J., Pirtskhalava, Tamar, Giorgadze, Nino, Wentworth, Mark, Fuhrmann-Stroissnigg, Heike, Niedernhofer, Laura J., Robbins, Paul D., Tchkonia, Tamara, Kirkland, James L.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.38 MB

english, 2017

16

26. Treatment Using a Therapeutic Peptide Inhibitor Against the Stress Mediator NFkB Delayed Age-Dependent Spinal Degeneration in an Accelerated Aging Mouse Model

Nam Vo, Jeremy Tilstra, Andria Robison, Arydas Usas, Gwendolyn Sowa, Rebecca Studer, Joon Lee, Laura Niedernhofer, James Kang

Journal:

The Spine Journal

Year:

2009

Language:

english

File:

PDF, 133 KB

english, 2009

17

Genetics of extreme human longevity to guide drug discovery for healthy ageing

Zhang, Zhengdong D., Milman, Sofiya, Lin, Jhih-Rong, Wierbowski, Shayne, Yu, Haiyuan, Barzilai, Nir, Gorbunova, Vera, Ladiges, Warren C., Niedernhofer, Laura J., Suh, Yousin, Robbins, Paul D., Vijg, J

Journal:

Nature Metabolism

Year:

2020

File:

PDF, 2.05 MB

2020

18

Genome instability and accelerated aging: The relevance for normal aging and life span extension

Jan H.J. Hoeijmakers, George Garinis, Ingrid van der Pluijm, Jay Mitchell, Jaan-Olle Andressoo, Karin Diderich, Astrid Lalai, Harm de Waard, Dolf Beems, Harry van Steeg, Laura Niedernhofer, Bert van d

Journal:

Year:

2006

Language:

english

File:

PDF, 70 KB

english, 2006

19

Deficiency of DNA repair nuclease ERCC1-XPF promotes prostate cancer progression in a tissue recombination model

Derek J. Matoka, Veronica Yao, Diana S. Harya, Jennifer L. Gregg, Andria R. Robinson, Laura J. Niedernhofer, Anil V. Parwani, Christoph Maier, Dean J. Bacich

Journal:

Year:

2012

Language:

english

File:

PDF, 1.21 MB

english, 2012

20

Xeroderma pigmentosum and other diseases of human premature aging and DNA repair: Molecules to patients

Laura J. Niedernhofer, Vilhelm A. Bohr, Miriam Sander, Kenneth H. Kraemer

Journal:

Mechanisms of Ageing and Development

Year:

2011

Language:

english

File:

PDF, 610 KB

english, 2011

21

Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model

Lavasani, Mitra, Robinson, Andria R., Lu, Aiping, Song, Minjung, Feduska, Joseph M., Ahani, Bahar, Tilstra, Jeremy S., Feldman, Chelsea H., Robbins, Paul D., Niedernhofer, Laura J., Huard, Johnny

Journal:

Nature Communications

Year:

2012

Language:

english

File:

PDF, 2.87 MB

english, 2012

22

Validation of ERCC1-XPF Immunodetection - Response

Niedernhofer, L. J., Bhagwat, N. R., Wood, R. D.

Journal:

Cancer Research

Year:

2010

Language:

english

File:

PDF, 53 KB

english, 2010

23

Attenuation of ataxia telangiectasia mutated signalling mitigates ageâassociated intervertebral disc degeneration

Han, Yingchao, Zhou, ChaoâMing, Shen, Hongxing, Tan, Jun, Dong, Qing, Zhang, Lei, McGowan, Sara J., Zhao, Jing, Sowa, Gwendolyn A., Kang, James D., Niedernhofer, Laura J., Robbins, Paul D., Vo, Nam

Journal:

Year:

2020

File:

PDF, 2.35 MB

2020

24

Nucleotide excision repair deficient mouse models and neurological disease

Laura J. Niedernhofer

Journal:

Year:

2008

Language:

english

File:

PDF, 820 KB

english, 2008

25

Spine degeneration in a murine model of chronic human tobacco smokers

D. Wang, L.A. Nasto, P. Roughley, A.S. Leme, A.M. Houghton, A. Usas, G. Sowa, J. Lee, L. Niedernhofer, S. Shapiro, J. Kang, N. Vo

Journal:

Osteoarthritis and Cartilage

Year:

2012

Language:

english

File:

PDF, 1.39 MB

english, 2012

26

The XPA-binding domain of ERCC1 Is Required for Nucleotide Excision Repair but Not Other DNA Repair Pathways

Orelli, B., McClendon, T. B., Tsodikov, O. V., Ellenberger, T., Niedernhofer, L. J., Scharer, O. D.

Journal:

Journal of Biological Chemistry

Year:

2010

Language:

english

File:

PDF, 1.76 MB

english, 2010

27

Modeling Alzheimer’s disease in progeria mice. An age-related concept

Sharma, Kavita, Darvas, Martin, Keene, C. Dirk, Niedernhofer, Laura J., Ladiges, Warren

Journal:

Pathobiology of Aging & Age-related Diseases

Year:

2018

Language:

english

File:

PDF, 848 KB

english, 2018

28

Mouse models of Fanconi anemia

Kalindi Parmar, Alan D’Andrea, Laura J. Niedernhofer

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2009

Language:

english

File:

PDF, 203 KB

english, 2009

29

Fanconi Anemia (Cross)linked to DNA Repair

Laura J. Niedernhofer, Astrid S. Lalai, Jan H.J. Hoeijmakers

Journal:

Year:

2005

Language:

english

File:

PDF, 736 KB

english, 2005

30

Advances in Understanding the Complex Mechanisms of DNA Interstrand Cross-Link Repair

Clauson, C., Scharer, O. D., Niedernhofer, L.

Journal:

Cold Spring Harbor Perspectives in Biology

Year:

2013

Language:

english

File:

PDF, 1.12 MB

english, 2013

31

In vivo detection and replication studies of α-anomeric lesions of 2′-deoxyribonucleosides

Amato, Nicholas J., Zhai, Qianqian, Navarro, Diana C., Niedernhofer, Laura J., Wang, Yinsheng

Journal:

Nucleic Acids Research

Year:

2015

Language:

english

File:

PDF, 3.86 MB

english, 2015

32

Cytoskeleton stiffness regulates cellular senescence and innate immune response in HutchinsonâGilford Progeria Syndrome

Mu, Xiaodong, Tseng, Chieh, Hambright, William S., Matre, Polina, Lin, ChihâYi, Chanda, Palas, Chen, Wanqun, Gu, Jianhua, Ravuri, Sudheer, Cui, Yan, Zhong, Ling, Cooke, John P., Niedernhofer, Laura

Journal:

Year:

2020

File:

PDF, 1.67 MB

2020

33

Mutagenic and genotoxic effects of three vinyl chloride-induced DNA lesions: 1,N6-ethenoadenine, 3,N4-ethenocytosine, and 4-amino-5-(imidazol-2-yl)imidazole

Basu, Ashis K., Wood, Michael L., Niedernhofer, Laura J., Ramos, Leilani A., Essigmann, John M.

Journal:

Year:

1993

Language:

english

File:

PDF, 2.11 MB

english, 1993

34

Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms

Schumacher, Björn, van der Pluijm, Ingrid, Moorhouse, Michael J., Kosteas, Theodore, Robinson, Andria Rasile, Suh, Yousin, Breit, Timo M., van Steeg, Harry, Niedernhofer, Laura J., van IJcken, Wilfred

Journal:

Year:

2008

Language:

english

File:

PDF, 644 KB

english, 2008

35

Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan

Laura J. Niedernhofer, Paul D. Robbins

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2008

Language:

english

File:

PDF, 342 KB

english, 2008

36

Simultaneous Quantification of Methylated Cytidine and Adenosine in Cellular and Tissue RNA by Nano-Flow Liquid Chromatography–Tandem Mass Spectrometry Coupled with the Stable Isotope-Dilution Method

Fu, Lijuan, Amato, Nicholas J., Wang, Pengcheng, McGowan, Sara J., Niedernhofer, Laura J., Wang, Yinsheng

Journal:

Analytical Chemistry

Year:

2015

Language:

english

File:

PDF, 786 KB

english, 2015

37

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

Niedernhofer, Laura J., Garinis, George A., Raams, Anja, Lalai, Astrid S., Robinson, Andria Rasile, Appeldoorn, Esther, Odijk, Hanny, Oostendorp, Roos, Ahmad, Anwaar, van Leeuwen, Wibeke

Journal:

Year:

2006

Language:

english

File:

PDF, 1002 KB

english, 2006

38

Downregulation of cholesterol biosynthesis genes in the forebrain of ERCC1-deficient mice

Scott C. Smith, Andria R. Robinson, Laura J. Niedernhofer, Michal Hetman

Journal:

Neurobiology of Disease

Year:

2012

Language:

english

File:

PDF, 752 KB

english, 2012

39

Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism

Flores, Rafael R., Clauson, Cheryl L., Cho, Joonseok, Lee, Byeong-Chel, McGowan, Sara J., Baker, Darren J., Niedernhofer, Laura J., Robbins, Paul D.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.09 MB

english, 2017

40

Neurodegeneration as the presenting symptom in 2 adults with xeroderma pigmentosum complementation group F

Shanbhag, Niraj M., Geschwind, Michael D., DiGiovanna, John J., Groden, Catherine, Godfrey, Rena, Yousefzadeh, Matthew J., Wade, Erin A., Niedernhofer, Laura J., Malicdan, May Christine V., Kraemer, K

Journal:

Neurology: Genetics

Year:

2018

Language:

english

File:

PDF, 507 KB

english, 2018

41

First Reported Patient with Human ERCC1 Deficiency Has Cerebro-Oculo-Facio-Skeletal Syndrome with a Mild Defect in Nucleotide Excision Repair and Severe Developmental Failure

Nicolaas G.J. Jaspers, Anja Raams, Margherita Cirillo Silengo, Nils Wijgers, Laura J. Niedernhofer, Andria Rasile Robinson, Giuseppina Giglia-Mari, Deborah Hoogstraten, Wim J. Kleijer, Jan H.J. Hoeijm

Journal:

The American Journal of Human Genetics

Year:

2007

Language:

english

File:

PDF, 2.32 MB

english, 2007

42

A quantitative assay for assessing the effects of DNA lesions on transcription

You, Changjun, Dai, Xiaoxia, Yuan, Bifeng, Wang, Jin, Wang, Jianshuang, Brooks, Philip J, Niedernhofer, Laura J, Wang, Yinsheng

Journal:

Nature Chemical Biology

Year:

2012

Language:

english

File:

PDF, 617 KB

english, 2012

43

Age-related dystrophic changes in corneal endothelium from DNA repair-deficient mice

Roh, Danny S., Du, Yiqin, Gabriele, Michelle L., Robinson, Andria R., Niedernhofer, Laura J., Funderburgh, James L.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.06 MB

english, 2013

44

Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration

Nasto, Luigi A., Robinson, Andria R., Ngo, Kevin, Clauson, Cheryl L., Dong, Qing, St. Croix, Claudette, Sowa, Gwendolyn, Pola, Enrico, Robbins, Paul D., Kang, James, Niedernhofer, Laura J., Wipf, Pete

Journal:

Journal of Orthopaedic Research

Year:

2013

Language:

english

File:

PDF, 1.56 MB

english, 2013

45

XPF Expression Correlates with Clinical Outcome in Squamous Cell Carcinoma of the Head and Neck

Vaezi, A., Wang, X., Buch, S., Gooding, W., Wang, L., Seethala, R. R., Weaver, D. T., D'Andrea, A. D., Argiris, A., Romkes, M., Niedernhofer, L. J., Grandis, J. R.

Journal:

Clinical Cancer Research

Year:

2011

Language:

english

File:

PDF, 818 KB

english, 2011

46

NF-κB Negatively Impacts the Myogenic Potential of Muscle-derived Stem Cells

Lu, Aiping, Proto, Jonathan D, Guo, Lulin, Tang, Ying, Lavasani, Mitra, Tilstra, Jeremy S, Niedernhofer, Laura J, Wang, Bing, Guttridge, Denis C, Robbins, Paul D, Huard, Johnny

Journal:

Molecular Therapy

Year:

2012

Language:

english

File:

PDF, 639 KB

english, 2012

47

Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms: Table 1.

Burd, Christin E., Gill, Matthew S., Niedernhofer, Laura J., Robbins, Paul D., Austad, Steven N., Barzilai, Nir, Kirkland, James L.

Journal:

The Journals of Gerontology Series A Biological Sciences and Medical Sciences

Year:

2016

Language:

english

File:

PDF, 628 KB

english, 2016

48

Creating the Next Generation of Translational Geroscientists

Newman, John C., Sokoloski, Julie L., Robbins, Paul D., Niedernhofer, Laura J., Reed, May J., Wei, Jeanne, Austad, Steven N., Barzilai, Nir, Cohen, Harvey Jay, Kuchel, George A., Kirkland, James L., P

Journal:

Journal of the American Geriatrics Society

Year:

2019

File:

PDF, 346 KB

2019

49

Multiple DNA Binding Domains Mediate the Function of the ERCC1-XPF Protein in Nucleotide Excision Repair

Su, Y., Orelli, B., Madireddy, A., Niedernhofer, L. J., Scharer, O. D.

Journal:

Journal of Biological Chemistry

Year:

2012

Language:

english

File:

PDF, 1.81 MB

english, 2012

50

Fanconi anemia: A paradigm of discovering molecular pathways from patients

Paul R. Andreassen, Laura J. Niedernhofer

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2009

Language:

english

File:

PDF, 101 KB

english, 2009

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